Iron(III) Complexes with Hydrogen Peroxide which Can Discriminate Two Reaction Types; Oxidation (H-Atom Abstraction) and Oxygenation Reaction

Iron(III)-NTA (nitrilotriacetic acid) solution shows high activity for oxidative degradation of 2'-deoxyribose in the presence of hydrogen peroxide, whereas its activity of Fe(III)-TFD A (2-aminomethyltetrahydrofuran-N,N-diacetic acid) is negligible under the same experimental conditions; however the latter solution exhibits abnormally higher reactivity for oxygenation reaction at 8-position of 2'-deoxyguanosine than other iron(III) chelates examined. These results suggest that oxidative degradation of deoxyribose and the oxygenation of deoxy^uanosine are caused by a different iron(III)-peroxide species.